Eva Dřízgová-Jirušová is a sought-after opera and concert repertoire. She is a foremost soloist of the National Moravian-Silesian Theatre in Ostrava and a regular guest of foremost opera houses in the Czech and Slovak Republic. She regularly performs in The National Theatre in Prague, The Prague State Opera, The National Theatre in Brno and in The Slovak National Theatre in Bratislava. Her repertoire includes Mařenka (The Bartered Bride), Jitka (Dalibor), Rusalka, Vixen (The Cunning Little Vixen) and, from the world repertoire above all Donna Anna (Don Giovanni), Violetta (La traviata), Desdemona (Otello), Cio-Cio-San (Madama Butterfly), Mimi (La Bohème), Liu (Turandot) and Adina (L´elisir d´amore). In 1996 she was awarded the prestigious Thalia prize for the best female performance in the opera field for her role of Mimi (La Bohème) and in 1998 she received the same prize for the title role in Debussy's Pelléas et Mélisande which she performed at her home stage in Ostrava.

Her vocal and technical disposition enables her to embrace a very wide repertoire in operatic as well as cantata, oratory and song works, notwithstanding the symphonic works by Richard Strauss and Gustav Mahler. Thanks to her musicality she is also a sought-after exponent of contemporary music. She has performed in almost all European countries (a tour of Finland and Spain and numerous appearances in Italy, Vatican, Germany, Poland, Estonia and Benelux) but also in Japan where she introduced herself among others in the title role of Janáček's The Cunning Little Vixen in the Japanese premiere of this opera with Tokyo Symphonic Orchestra. She cooperated with the La Scala in the same role. Other foreign engagements worth mentioning include her appearance in the Salzburg Festspielhaus as Dvořák's Rusalka and Verdi's Violetta (La traviata).

An important place in her concert repertoire is taken by the works of Bach, Boccherini, Mozart, Rossini, Verdi, Dvořák, Janáček, Mahler, Shostakovich and numerous other authors. A significant oratory, Massenet's Marie Magdeleine was her debut at the Prague Spring International Festival in 1996 and later at Europäische Wochen Passau.

Eva Dřízgová-Jirušová cooperates with foremost Czech orchestras including the Czech Philharmonic Orchestra, Prague Symphony Orchestra FOK, Brno Philharmonic and Janáček Philharmonic Ostrava. She regularly performs with prestigious foreign orchestras: Munich Philharmonic, Gürzenich Orchester Köln, Carlo Coccia Symphonic Orchestra in Novara, Warsaw Radio Orchestra, Estonian Philharmonic in Tallinn or Slovak Philharmonic.

She took part in many CD recordings; she cooperates with Czech Television and Radio.